Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's disease
Identifieur interne : 000C92 ( Main/Corpus ); précédent : 000C91; suivant : 000C93Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's disease
Auteurs : Rossitza Baltadjieva ; Nir Giladi ; Leor Gruendlinger ; Chava Peretz ; Jeffrey M. HausdorffSource :
- European Journal of Neuroscience [ 0953-816X ] ; 2006-09.
English descriptors
- KwdEn :
Abstract
Little is known about the gait characteristics of subjects with de novo Parkinson's disease (PD). We hypothesized that alterations in the spatio‐temporal characteristics of gait will already be quantifiable in these patients. The gait of 35 patients with idiopathic PD (mean age 60 years) who were in the early stages of the disease (Hoehn and Yahr stage 1.8 ± 0.5, median 2.0, range 1.0–2.5) and were not yet treated with any anti‐parkinsonian medications were compared with the gait of age‐ and sex‐matched healthy controls (n = 22). The patients walked more slowly and with reduced swing times while also exhibiting increased left/right swing asymmetry and marked inconsistencies in the timing of gait. By contrast, significant group differences in the peak forces at heel‐strike and in the stride‐to‐stride variability of the ground reaction forces (a reflection of muscle output consistency) were not observed. These findings indicate that in de novo PD, an altered gait pattern is observed, even though dramatic changes in the gait pattern may not yet be apparent visually (e.g. fairly intact gait speed). Furthermore, the results demonstrate that the observed alterations are not just side‐effects of treatments or complications of the disease. Instead, there is evidence for motor programming deficits in gait, as revealed by increased gait variability and asymmetry in timing. PD apparently impinges on the regulation of a consistent gait rhythm, even early in the course of the disease when observed alterations are not the result of any pharmacologic treatment.
Url:
DOI: 10.1111/j.1460-9568.2006.05033.x
Links to Exploration step
ISTEX:A60571332233687595FDE04DFAE98F176BB4EC14Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's disease</title><author><name sortKey="Baltadjieva, Rossitza" sort="Baltadjieva, Rossitza" uniqKey="Baltadjieva R" first="Rossitza" last="Baltadjieva">Rossitza Baltadjieva</name><affiliation><mods:affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</mods:affiliation></affiliation></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><affiliation><mods:affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation></author><author><name sortKey="Gruendlinger, Leor" sort="Gruendlinger, Leor" uniqKey="Gruendlinger L" first="Leor" last="Gruendlinger">Leor Gruendlinger</name><affiliation><mods:affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</mods:affiliation></affiliation></author><author><name sortKey="Peretz, Chava" sort="Peretz, Chava" uniqKey="Peretz C" first="Chava" last="Peretz">Chava Peretz</name><affiliation><mods:affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation></author><author><name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M." last="Hausdorff">Jeffrey M. Hausdorff</name><affiliation><mods:affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medicine, Harvard Medical School, Boston, MA, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A60571332233687595FDE04DFAE98F176BB4EC14</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1111/j.1460-9568.2006.05033.x</idno><idno type="url">https://api.istex.fr/document/A60571332233687595FDE04DFAE98F176BB4EC14/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000C92</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's disease</title><author><name sortKey="Baltadjieva, Rossitza" sort="Baltadjieva, Rossitza" uniqKey="Baltadjieva R" first="Rossitza" last="Baltadjieva">Rossitza Baltadjieva</name><affiliation><mods:affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</mods:affiliation></affiliation></author><author><name sortKey="Giladi, Nir" sort="Giladi, Nir" uniqKey="Giladi N" first="Nir" last="Giladi">Nir Giladi</name><affiliation><mods:affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation></author><author><name sortKey="Gruendlinger, Leor" sort="Gruendlinger, Leor" uniqKey="Gruendlinger L" first="Leor" last="Gruendlinger">Leor Gruendlinger</name><affiliation><mods:affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</mods:affiliation></affiliation></author><author><name sortKey="Peretz, Chava" sort="Peretz, Chava" uniqKey="Peretz C" first="Chava" last="Peretz">Chava Peretz</name><affiliation><mods:affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation></author><author><name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M." last="Hausdorff">Jeffrey M. Hausdorff</name><affiliation><mods:affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medicine, Harvard Medical School, Boston, MA, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neuroscience</title><idno type="ISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2006-09">2006-09</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1815">1815</biblScope><biblScope unit="page" to="1820">1820</biblScope></imprint><idno type="ISSN">0953-816X</idno></series><idno type="istex">A60571332233687595FDE04DFAE98F176BB4EC14</idno><idno type="DOI">10.1111/j.1460-9568.2006.05033.x</idno><idno type="ArticleID">EJN5033</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0953-816X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>basal ganglia</term><term>gait variability</term><term>motor programming</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Little is known about the gait characteristics of subjects with de novo Parkinson's disease (PD). We hypothesized that alterations in the spatio‐temporal characteristics of gait will already be quantifiable in these patients. The gait of 35 patients with idiopathic PD (mean age 60 years) who were in the early stages of the disease (Hoehn and Yahr stage 1.8 ± 0.5, median 2.0, range 1.0–2.5) and were not yet treated with any anti‐parkinsonian medications were compared with the gait of age‐ and sex‐matched healthy controls (n = 22). The patients walked more slowly and with reduced swing times while also exhibiting increased left/right swing asymmetry and marked inconsistencies in the timing of gait. By contrast, significant group differences in the peak forces at heel‐strike and in the stride‐to‐stride variability of the ground reaction forces (a reflection of muscle output consistency) were not observed. These findings indicate that in de novo PD, an altered gait pattern is observed, even though dramatic changes in the gait pattern may not yet be apparent visually (e.g. fairly intact gait speed). Furthermore, the results demonstrate that the observed alterations are not just side‐effects of treatments or complications of the disease. Instead, there is evidence for motor programming deficits in gait, as revealed by increased gait variability and asymmetry in timing. PD apparently impinges on the regulation of a consistent gait rhythm, even early in the course of the disease when observed alterations are not the result of any pharmacologic treatment.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Rossitza Baltadjieva</name><affiliations><json:string>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</json:string></affiliations></json:item><json:item><name>Nir Giladi</name><affiliations><json:string>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</json:string><json:string>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</json:string></affiliations></json:item><json:item><name>Leor Gruendlinger</name><affiliations><json:string>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</json:string></affiliations></json:item><json:item><name>Chava Peretz</name><affiliations><json:string>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</json:string><json:string>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</json:string></affiliations></json:item><json:item><name>Jeffrey M. Hausdorff</name><affiliations><json:string>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</json:string><json:string>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</json:string><json:string>Department of Medicine, Harvard Medical School, Boston, MA, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>basal ganglia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>gait variability</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>motor programming</value></json:item></subject><articleId><json:string>EJN5033</json:string></articleId><language><json:string>eng</json:string></language><abstract>Little is known about the gait characteristics of subjects with de novo Parkinson's disease (PD). We hypothesized that alterations in the spatio‐temporal characteristics of gait will already be quantifiable in these patients. The gait of 35 patients with idiopathic PD (mean age 60 years) who were in the early stages of the disease (Hoehn and Yahr stage 1.8 ± 0.5, median 2.0, range 1.0–2.5) and were not yet treated with any anti‐parkinsonian medications were compared with the gait of age‐ and sex‐matched healthy controls (n = 22). The patients walked more slowly and with reduced swing times while also exhibiting increased left/right swing asymmetry and marked inconsistencies in the timing of gait. By contrast, significant group differences in the peak forces at heel‐strike and in the stride‐to‐stride variability of the ground reaction forces (a reflection of muscle output consistency) were not observed. These findings indicate that in de novo PD, an altered gait pattern is observed, even though dramatic changes in the gait pattern may not yet be apparent visually (e.g. fairly intact gait speed). Furthermore, the results demonstrate that the observed alterations are not just side‐effects of treatments or complications of the disease. Instead, there is evidence for motor programming deficits in gait, as revealed by increased gait variability and asymmetry in timing. PD apparently impinges on the regulation of a consistent gait rhythm, even early in the course of the disease when observed alterations are not the result of any pharmacologic treatment.</abstract><qualityIndicators><score>7.663</score><pdfVersion>1.3</pdfVersion><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>3</keywordCount><abstractCharCount>1572</abstractCharCount><pdfWordCount>4795</pdfWordCount><pdfCharCount>29020</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>239</abstractWordCount></qualityIndicators><title>Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's disease</title><genre><json:string>article</json:string></genre><host><volume>24</volume><publisherId><json:string>EJN</json:string></publisherId><pages><total>6</total><last>1820</last><first>1815</first></pages><issn><json:string>0953-816X</json:string></issn><issue>6</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1460-9568</json:string></eissn><title>European Journal of Neuroscience</title><doi><json:string>10.1111/(ISSN)1460-9568</json:string></doi></host><publicationDate>2006</publicationDate><copyrightDate>2006</copyrightDate><doi><json:string>10.1111/j.1460-9568.2006.05033.x</json:string></doi><id>A60571332233687595FDE04DFAE98F176BB4EC14</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/A60571332233687595FDE04DFAE98F176BB4EC14/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/A60571332233687595FDE04DFAE98F176BB4EC14/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A60571332233687595FDE04DFAE98F176BB4EC14/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2006</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's disease</title><author><persName><forename type="first">Rossitza</forename><surname>Baltadjieva</surname></persName><note type="biography">R.B. and N.G. contributed equally to this work.</note><affiliation>R.B. and N.G. contributed equally to this work.</affiliation><affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</affiliation></author><author><persName><forename type="first">Nir</forename><surname>Giladi</surname></persName><note type="biography">R.B. and N.G. contributed equally to this work.</note><affiliation>R.B. and N.G. contributed equally to this work.</affiliation><affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</affiliation><affiliation>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</affiliation></author><author><persName><forename type="first">Leor</forename><surname>Gruendlinger</surname></persName><affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</affiliation></author><author><persName><forename type="first">Chava</forename><surname>Peretz</surname></persName><affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</affiliation><affiliation>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</affiliation></author><author><persName><forename type="first">Jeffrey M.</forename><surname>Hausdorff</surname></persName><affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</affiliation><affiliation>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</affiliation><affiliation>Department of Medicine, Harvard Medical School, Boston, MA, USA</affiliation></author></analytic><monogr><title level="j">European Journal of Neuroscience</title><idno type="pISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><idno type="DOI">10.1111/(ISSN)1460-9568</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2006-09"></date><biblScope unit="volume">24</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1815">1815</biblScope><biblScope unit="page" to="1820">1820</biblScope></imprint></monogr><idno type="istex">A60571332233687595FDE04DFAE98F176BB4EC14</idno><idno type="DOI">10.1111/j.1460-9568.2006.05033.x</idno><idno type="ArticleID">EJN5033</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2006</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Little is known about the gait characteristics of subjects with de novo Parkinson's disease (PD). We hypothesized that alterations in the spatio‐temporal characteristics of gait will already be quantifiable in these patients. The gait of 35 patients with idiopathic PD (mean age 60 years) who were in the early stages of the disease (Hoehn and Yahr stage 1.8 ± 0.5, median 2.0, range 1.0–2.5) and were not yet treated with any anti‐parkinsonian medications were compared with the gait of age‐ and sex‐matched healthy controls (n = 22). The patients walked more slowly and with reduced swing times while also exhibiting increased left/right swing asymmetry and marked inconsistencies in the timing of gait. By contrast, significant group differences in the peak forces at heel‐strike and in the stride‐to‐stride variability of the ground reaction forces (a reflection of muscle output consistency) were not observed. These findings indicate that in de novo PD, an altered gait pattern is observed, even though dramatic changes in the gait pattern may not yet be apparent visually (e.g. fairly intact gait speed). Furthermore, the results demonstrate that the observed alterations are not just side‐effects of treatments or complications of the disease. Instead, there is evidence for motor programming deficits in gait, as revealed by increased gait variability and asymmetry in timing. PD apparently impinges on the regulation of a consistent gait rhythm, even early in the course of the disease when observed alterations are not the result of any pharmacologic treatment.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>basal ganglia</term></item><item><term>gait variability</term></item><item><term>motor programming</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/A60571332233687595FDE04DFAE98F176BB4EC14/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1460-9568</doi><issn type="print">0953-816X</issn><issn type="electronic">1460-9568</issn><idGroup><id type="product" value="EJN"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROSCIENCE">European Journal of Neuroscience</title></titleGroup></publicationMeta><publicationMeta level="part" position="09006"><doi origin="wiley">10.1111/ejn.2006.24.issue-6</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue" number="6">6</numbering></numberingGroup><coverDate startDate="2006-09">September 2006</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="31" status="forIssue"><doi origin="wiley">10.1111/j.1460-9568.2006.05033.x</doi><idGroup><id type="unit" value="EJN5033"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">Research Reports</title></titleGroup><eventGroup><event type="firstOnline" date="2006-09-21"></event><event type="publishedOnlineFinalForm" date="2006-09-21"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-02"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-12"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="1815">1815</numbering><numbering type="pageLast" number="1820">1820</numbering></numberingGroup><correspondenceTo>Dr J. M. Hausdorff, <sup>1</sup>Laboratory for Gait & Neurodynamics, as above.
E‐mail: <email>jhausdor@bidmc.harvard.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:EJN.EJN5033.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 1 February 2006, revised 25 June 2006, accepted 3 July 2006</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="4"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="25"></count><count type="wordTotal" number="4141"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Marked alterations in the gait timing and rhythmicity of patients with <i>de novo</i> Parkinson's disease</title><title type="shortAuthors">R. Baltadjieva <i>et al.</i></title><title type="short">Gait changes in <i>de novo</i> PD</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" noteRef="#fn1"><personName><givenNames>Rossitza</givenNames><familyName>Baltadjieva</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1 #a2" noteRef="#fn1"><personName><givenNames>Nir</givenNames><familyName>Giladi</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Leor</givenNames><familyName>Gruendlinger</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1 #a2"><personName><givenNames>Chava</givenNames><familyName>Peretz</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1 #a2 #a3"><personName><givenNames>Jeffrey M.</givenNames><familyName>Hausdorff</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="IL"><unparsedAffiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="IL"><unparsedAffiliation>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="US"><unparsedAffiliation>Department of Medicine, Harvard Medical School, Boston, MA, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">basal ganglia</keyword><keyword xml:id="k2">gait variability</keyword><keyword xml:id="k3">motor programming</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Little is known about the gait characteristics of subjects with <i>de novo</i> Parkinson's disease (PD). We hypothesized that alterations in the spatio‐temporal characteristics of gait will already be quantifiable in these patients. The gait of 35 patients with idiopathic PD (mean age 60 years) who were in the early stages of the disease (Hoehn and Yahr stage 1.8 ± 0.5, median 2.0, range 1.0–2.5) and were not yet treated with any anti‐parkinsonian medications were compared with the gait of age‐ and sex‐matched healthy controls (<i>n</i> = 22). The patients walked more slowly and with reduced swing times while also exhibiting increased left/right swing asymmetry and marked inconsistencies in the timing of gait. By contrast, significant group differences in the peak forces at heel‐strike and in the stride‐to‐stride variability of the ground reaction forces (a reflection of muscle output consistency) were not observed. These findings indicate that in <i>de novo</i> PD, an altered gait pattern is observed, even though dramatic changes in the gait pattern may not yet be apparent visually (e.g. fairly intact gait speed). Furthermore, the results demonstrate that the observed alterations are not just side‐effects of treatments or complications of the disease. Instead, there is evidence for motor programming deficits in gait, as revealed by increased gait variability and asymmetry in timing. PD apparently impinges on the regulation of a consistent gait rhythm, even early in the course of the disease when observed alterations are not the result of any pharmacologic treatment.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><label>*</label><p> R.B. and N.G. contributed equally to this work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's disease</title></titleInfo><titleInfo type="abbreviated"><title>Gait changes in de novo PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Marked alterations in the gait timing and rhythmicity of patients with</title></titleInfo><name type="personal"><namePart type="given">Rossitza</namePart><namePart type="family">Baltadjieva</namePart><affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</affiliation><description>R.B. and N.G. contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nir</namePart><namePart type="family">Giladi</namePart><affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</affiliation><affiliation>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</affiliation><description>R.B. and N.G. contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Leor</namePart><namePart type="family">Gruendlinger</namePart><affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chava</namePart><namePart type="family">Peretz</namePart><affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</affiliation><affiliation>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jeffrey M.</namePart><namePart type="family">Hausdorff</namePart><affiliation>Laboratory for Gait & Neurodynamics, Movement Disorders Unit and NPF Center for Parkinson's Disease, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel</affiliation><affiliation>Sackler School of Medicine, Tel‐Aviv University, Tel Aviv, Israel</affiliation><affiliation>Department of Medicine, Harvard Medical School, Boston, MA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2006-09</dateIssued><edition>Received 1 February 2006, revised 25 June 2006, accepted 3 July 2006</edition><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">4</extent><extent unit="references">25</extent><extent unit="words">4141</extent></physicalDescription><abstract lang="en">Little is known about the gait characteristics of subjects with de novo Parkinson's disease (PD). We hypothesized that alterations in the spatio‐temporal characteristics of gait will already be quantifiable in these patients. The gait of 35 patients with idiopathic PD (mean age 60 years) who were in the early stages of the disease (Hoehn and Yahr stage 1.8 ± 0.5, median 2.0, range 1.0–2.5) and were not yet treated with any anti‐parkinsonian medications were compared with the gait of age‐ and sex‐matched healthy controls (n = 22). The patients walked more slowly and with reduced swing times while also exhibiting increased left/right swing asymmetry and marked inconsistencies in the timing of gait. By contrast, significant group differences in the peak forces at heel‐strike and in the stride‐to‐stride variability of the ground reaction forces (a reflection of muscle output consistency) were not observed. These findings indicate that in de novo PD, an altered gait pattern is observed, even though dramatic changes in the gait pattern may not yet be apparent visually (e.g. fairly intact gait speed). Furthermore, the results demonstrate that the observed alterations are not just side‐effects of treatments or complications of the disease. Instead, there is evidence for motor programming deficits in gait, as revealed by increased gait variability and asymmetry in timing. PD apparently impinges on the regulation of a consistent gait rhythm, even early in the course of the disease when observed alterations are not the result of any pharmacologic treatment.</abstract><subject lang="en"><genre>Keywords</genre><topic>basal ganglia</topic><topic>gait variability</topic><topic>motor programming</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neuroscience</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0953-816X</identifier><identifier type="eISSN">1460-9568</identifier><identifier type="DOI">10.1111/(ISSN)1460-9568</identifier><identifier type="PublisherID">EJN</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>1815</start><end>1820</end><total>6</total></extent></part></relatedItem><identifier type="istex">A60571332233687595FDE04DFAE98F176BB4EC14</identifier><identifier type="DOI">10.1111/j.1460-9568.2006.05033.x</identifier><identifier type="ArticleID">EJN5033</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C92 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000C92 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:A60571332233687595FDE04DFAE98F176BB4EC14
|texte= Marked alterations in the gait timing and rhythmicity of patients with de novo Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |